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Project information
New catalysts and reagents for sustainable green syntheses and combinatorial syntheses

Project Identification
2A-1TP1/090
Project Period
11/2006 - 12/2011
Investor / Pogramme / Project type
Ministry of Industry and Trade of the CR
  • Sustainable welfare
MU Faculty or unit
Faculty of Science
Keywords
Sustainable development, solid support, catalysts, phase transfer catalysis, sonochemistry, keratin, polymers, quarternery ammonium salts, 4-N,N-dialkylaminopyridines, benzotriazole, activation, combinatorial syntheses, cyanohydrines, 1H-pyridine-4-one,
Cooperating Organization
Gasmeter-Water Brno
  • Responsible person Ing. Dušan Vilda
  • Responsible person Ing. Dušan Vilda
Lučební závody DRASLOVKA

The solution of project will be concentrated to preparation of new catalysts and reagents for sustainable green syntheses and combinatorial syntheses, respectively that will be immobilized by support on natural keratin, polyacrylamide and liphophilic parraffin phases. Further it will be studies of their application in sophisticated chemical syntheses and small-tonnage synthetic processes. The catalytic centres will be the structures that can be used for anione transfer during the phase transfer catalysis (PTC) processes (quarternery ammonium salts with different lipophility), structures for activation and transfer of acyl synthons incl. heteroanalogues in the course of inverse PTC (based on 4-N,N-dialkylaminopyridines,
9--N,N-dialkylaminoacridines or pyridine-1-oxides). The reagents for combinatorial syntheses will be via benzene skeleton bonded supported benzotriazoles derived in position 1 first of all by reactions with cyanohydrines. Applications of supported catalysts mentioned above will be studied on model alkyl, acyl and similar reactions, further on condensation, elimination and redox reactions, eventually under ultrasound action support. Reactivity and transformation of supported benzotriazole derived by cyanohydrines will be studied in terms of cyano group transformation (hydrolyses, reductions) and their derivatisation on alpha carbon atom. The formed structures will be transformated into atypical amino acid and proteine derivatives. The part of solution will be also the search of occasions for the 1H-pyridine-4-one synthesis via catalytic oxidation, followed by transformation of pyridone structures in structural motives applied in some catalytic systems (pyridine-4-carbonitrile, 4-N,N-dialkylamino-pyridines,
9-N,N-dialkylaminoacridines). In the course of solution the ultrasonic apparatus for laboratory and industrial synthesis support will be found.

Publications

Total number of publications: 68

2015

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