Project information
Vysoce efektivní systém založený na kapilární elektroforéze pro screening inhibitorů beta-sekretázy jako terapeutického cíle pro Alzheimerovu chorobu
(Alzheimer)
- Project Identification
- GA16-06106S
- Project Period
- 1/2016 - 12/2018
- Investor / Pogramme / Project type
-
Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
Hlavním cílem tohoto projektu je vývoj vysoce efektivního systému založeného na kapilární elektroforéze pro screening inhibitorů beta-sekretázy jako potenciálního terapeutického cíle pro léčbu Alzheimerovy choroby.
Publications
Total number of publications: 41
2017
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Beta-secretase kinetics detected by MALDI TOF MS
Year: 2017, type: Conference abstract
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Capillary electrophoresis-integrated immobilized enzyme reactor for screening of β-secretase inhibitors – potential anti-Alzheimer’s disease drugs
Year: 2017, type: Conference abstract
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Capillary electrophoresis-integrated immobilized enzyme reactor for β-secretase enzyme assays
Year: 2017, type: Conference abstract
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CE-C4D method for determination of beta-secretase activity as a tool for unbiased screening of potential drugs for patients suffering from Alzheimer’s disease
Year: 2017, type: Conference abstract
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Development and comprehensive comparison of two on-line capillary electrophoretic methods for beta-secretase inhibitor screening
Journal of Chromatography A, year: 2017, volume: 1518, edition: October, DOI
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METABOLIC RATIOS OF LANSOPRAZOLE TO 5-HYDROXYLANSOPRAZOLE AND LANSOPRAZOLE TO LANSOPRAZOLE SULFONE FOR PREDICTION OF CYP2C19 AND CYP3A4 METABOLIC ACTIVITY
Year: 2017, type: Conference abstract
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New IMER setup for metabolic studies in capillary electrophoresis using magnetic microparticles
Year: 2017, type:
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β-secretase enzyme assay by MALDI TOF MS
Year: 2017, type: Conference abstract
2016
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BACE enzyme kinetics detected by MALDI TOF mass spectrometry
CECE 2016, year: 2016
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Bile Acids, Nuclear Receptors and Cytochrome P450
Physiological Research, year: 2016, volume: 65, edition: Suppl. 4