doc. Mgr. Karel Kubíček, PhD.

Curriculum Vitae

Person-Related Identification Information

• doc. Mgr. Karel Kubíček, Ph.D., 19.09.1977 in Valtice, married, 2 children

Department

• Department of Condensed Matter Physics
  Masaryk University
  Kotlářská 2
  611 37 Brno
  Czech Republic
   
  
• CEITEC - Central European Institute of Technology
  Structural Biology of Gene Regulation
  Kamenice 753/5
  625 00 Brno
   
  T: +420 549 49 3253
  M: +420 731 28 76 16
  F: +420 541 211 214
  E: karelk(AT)physics.muni.cz
      karel.kubicek(AT)ceitec.muni.cz

Employment - Position

• Associate Professor in Biophysics
  
• Researcher @Laboratory of Structural Biology of Gene Regulation (prof. Richard Štefl)

Education and Academic Qualifications

• 2020-present: Associate Professor in Biophysics
• 2018 (5 months): Scientific exchange within Twinning project (TWINFUSYON) Johannes Kepler University Linz, Austria (prof. Kurt Hingerl)
• 2008-present: Researcher in the laboratory of prof. Richard Štefl
• 2007-2020: Assistant Professor for Biophysics at the Dept. Condensed Matter Physics, Faculty of Science, Masaryk University, Brno, Czech Republic
• 2005–2007: Postdoctoral researcher at the Max-Planck-Institute for Biophysical Chemistry in Göttingen, Department of NMR-based Structural Biology; studies of ligand–target interactions by solution NMR in the group of Dr. Teresa Carlomagno and Prof. Christian Griesinger.)
• 2001–2004: International doctorate in structural biology, Magnetic Resonance Center (CERM) in Florence, Italy. Degree awarded by University of Florence, Italy. Topic of Thesis: NMR Characterization of Protein–Protein and Protein–Cofactor Interactions (Supervisor Prof.Lucia Banci)
• 1996–2001: Masaryk University, Faculty of Science, Department of Theoretical and Physical Chemistry, final exams passed in June 2001. Topic of Thesis: Application of Residual Dipolar Interactions for Structure Determination of Biomolecules (Supervisor Prof. Vladimír Sklenář)
• 1992–1996: Technical College of Chemistry in Brno, final exams passed in 1996

Grants

• 2015-2018 GAČR standard grant
• 2011-2013 OP Vzdělávání pro konkurenceschopnost: Reforma a rozvoj výuky Biofyziky pro potřeby 21. století
• 2008-2010 GAČR postdoctoral grant

Teaching Activities

• 2013-present Organisation of Biophysical competition (http://physics.muni.cz/biophys/souteze.shtml)
• 2008-present Mentoring students
• 2008-present Teaching activities (biophysics, practical and theoretical NMR spectroscopy, experimental techniques in biophysical research)

Scientific and Research Activities

• Electron microscopy, NMR spectroscopy, AFM microscopy, protein-protein interactions, drug-design, protein-ligand interactions, SAXS, fluorescent anisotropy, isothermal titration calorimetry, molecular dynamics, electron microscopy ...

University Activities

• 2021-2023 Academic Senate of the Masaryk University Brno, Czech Rep.
• 2018-2020 Academic Senate of the Masaryk University Brno, Czech Rep.
• 2015-2017 Academic Senate of the Masaryk University Brno, Czech Rep.
• 2008-2011 Academic Senate of the Faculty of Science of the Masaryk University Brno, Czech Rep.
• 1998–2001 Academic Senate of the Masaryk University Brno, Czech Rep.
• 1996–2001 Academic Senate of the Faculty of Science of the Masaryk University Brno, Czech Rep.

Activities Outside University

• The Board of Biophysics @University of South Bohemia

Awards Related to Science and Research

• 2023 MUNI Scientist Award
• 2006–2007 DAAD scholarship within the program “Modern Applications of Biotechnology”
• 2001 Special prize of the Czech chemical society for the “Best presentation” on the Student scientific competition
• 2001 Chemistry section prize
• 2000 I. prize in the Student scientific competition
• 2000 Chemistry section prize

Major Publications

• DIKUNOVÁ, Alžbeta, Nikola NOSKOVÁ, Jan H. OVERBECK, Martin POLÁK, David STELZIG, David ZAPLETAL, Karel KUBÍČEK, Jiří NOVÁČEK, Remco SPRANGERS a Richard ŠTEFL. Assembly of the Xrn2/Rat1–Rai1–Rtt103 termination complexes in mesophilic and thermophilic organisms. Structure. Cell Press, 2025, roč. 33, č. 2, s. 300-310. ISSN 0969-2126. Dostupné z: https://dx.doi.org/10.1016/j.str.2024.11.010. URL info
• KADEŘÁVEK, Pavel, Karel KUBÍČEK a Lukáš ŽÍDEK. Chapter 16 - Interactions among the three protein states. In Timir Tripathi and Vladimir N. Uversky. The Three Functional States of Proteins. Structured, Intrinsically Disordered, and Phase Separated. 525 B ST, STE 1900, SAN DIEGO, CA 92101-: Academic Press, 2024, s. 297-313. The Three Functional States of Proteins Structured, Intrinsically Disordered, and Phase Separated. ISBN 978-0-443-21809-5. Dostupné z: https://dx.doi.org/10.1016/B978-0-443-21809-5.00022-3. URL info
• PAPAGEORGIOU, Anna, Michaela POSPÍŠILOVÁ, Jakub CIBULKA, Raghib ASHRAF, Christopher WAUDBY, Pavel KADEŘÁVEK, Volha MAROZ, Karel KUBÍČEK, Zbyněk PROKOP, Lumír KREJČÍ a Konstantinos TRIPSIANES. Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase. Nature Communications. Berlin: Nature, 2023, roč. 14, č. 1, s. 1-19. ISSN 2041-1723. Dostupné z: https://dx.doi.org/10.1038/s41467-023-42503-z. URL info
• ZAPLETAL, David, Karel KUBÍČEK, Petr SVOBODA a Richard ŠTEFL. Dicer structure and function: conserved and evolving features. EMBO reports. Wiley, 2023, roč. 24, č. 7, s. 1-13. ISSN 1469-221X. Dostupné z: https://dx.doi.org/10.15252/embr.202357215. URL info
• KASILIAUSKAITE, Aiste, Karel KUBÍČEK, Tomáš KLUMPLER, Martina ZÁNOVÁ, David ZAPLETAL, Eliska KOUTNA, Jiří NOVÁČEK a Richard ŠTEFL. Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly. Nucleic acids research. Oxford: Oxford University Press, 2022, roč. 50, č. 10, s. 5961-5973. ISSN 0305-1048. Dostupné z: https://dx.doi.org/10.1093/nar/gkac451. URL info
• ZAPLETAL, David, Eliska TABORSKA, Josef PASULKA, Radek MALIK, Karel KUBÍČEK, Martina ZÁNOVÁ, Christian MUCH, Marek ŠEBESTA, Valeria BUCCHERI, Filip HORVAT, Irena JENICKOVA, Michaela PROCHAZKOVA, Jan PROCHAZKA, Matyáš PINKAS, Jiří NOVÁČEK, Diego F JOSEPH, Radislav SEDLACEK, Carrie BERNECKY, Donal CARROLL, Richard ŠTEFL a Petr SVOBODA. Structural and functional basis of mammalian microRNA biogenesis by Dicer. Molecular Cell. CAMBRIDGE: CELL PRESS, 2022, roč. 82, č. 21, s. 4064-4079, 30 s. ISSN 1097-2765. Dostupné z: https://dx.doi.org/10.1016/j.molcel.2022.10.010. URL info
• BRÁZDA, Pavel, Magdaléna KREJČÍKOVÁ, Aiste KASILIAUSKAITE, Eliška ŠMIŘÁKOVÁ, Tomáš KLUMPLER, Robert VÁCHA, Karel KUBÍČEK a Richard ŠTEFL. Yeast Spt6 Reads Multiple Phosphorylation Patterns of RNA Polymerase II C-Terminal Domain In Vitro. Journal of Molecular Biology. Academic Press, 2020, roč. 432, č. 14, s. 4092-4107. ISSN 0022-2836. Dostupné z: https://dx.doi.org/10.1016/j.jmb.2020.05.007. URL info
• HAN, Z., Olga JASNOVIDOVA, N. HAIDARA, A. TUDEK, Karel KUBÍČEK, D. LIBRI, Richard ŠTEFL a O. PORRUA. Termination of non-coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD-mimicking region in Sen1. EMBO Journal. Hoboken (USA): WILEY-BLACKWELL, 2020, roč. 39, č. 7, s. 101548-101569. ISSN 0261-4189. Dostupné z: https://dx.doi.org/10.15252/embj.2019101548. URL info
• JASNOVIDOVA, Olga, Magdaléna KREJČÍKOVÁ, Karel KUBÍČEK a Richard ŠTEFL. Structural insight into recognition of phosphorylated threonine-4 of RNA polymerase II C-terminal domain by Rtt103p. EMBO reports. Hoboken: Wiley-Blackwell, 2017, roč. 18, č. 6, s. 906-913. ISSN 1469-221X. Dostupné z: https://dx.doi.org/10.15252/embr.201643723. URL info
• JASNOVIDOVA, Olga, Tomáš KLUMPLER, Karel KUBÍČEK, Sergei KALYNYCH, Pavel PLEVKA a Richard ŠTEFL. Structure and dynamics of the RNAPII CTDsome with Rtt103. Proceeding of the National Academy of Sciences of the USA. The Academy, 2017, roč. 114, č. 42, s. 11133-11138. ISSN 0027-8424. Dostupné z: https://dx.doi.org/10.1073/pnas.1712450114. URL info

2025/05/05