Project information
Czech National Infrastructure for Biological Data
(ELIXIR-CZ)
- Project Identification
- LM2015047
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
-
Central European Institute of Technology
- prof. RNDr. Jaroslav Koča, DrSc.
- RNDr. Petr Kulhánek, Ph.D.
- Mgr. Martin Prokop, Ph.D.
- RNDr. Tomáš Raček, Ph.D.
- RNDr. David Sehnal, Ph.D.
- doc. RNDr. Radka Svobodová, Ph.D.
- prof. RNDr. Michaela Wimmerová, Ph.D.
- Other MU Faculty/Unit
-
Institute of Computer Science
- prof. RNDr. Luděk Matyska, CSc.
- Mgr. Ivana Křenková
- Mgr. Slávek Licehammer
- RNDr. Michal Procházka, Ph.D.
- Mgr. Zdeněk Salvet
- Project Website
- https://www.elixir-czech.cz/
- Cooperating Organization
-
Institute of Microbiology of the ASCR, v. v. i.
Institute of Molecular Genetics of the ASCR, v. v. i.
Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
- Responsible person RNDr. Jiří Vondrášek, CSc.
University of South Bohemia České Budějovice
Charles University
Palacký University, Olomouc
Prague Institute of Chemical Technology
St. Anne's University Hospital Brno
Biological Centre of the ASCR, v. v. i.
Institute of Biotechnology CAS
It is a current global trend that life science experiments generate an immense and steadily increasing volume of data. The Czech Republic feels this trend very strongly, because several new life science infrastructures were successfully established here, and they produce large amounts of data. It is necessary to store the data, safely manipulate with them, efficiently extract key information, etc. ELIXIR CZ is an infrastructure which is prepared to accept this challenge.
Thus, ELIXIR CZ aims to create a sustainable infrastructure for storing, processing and analysis of life science data in the Czech Republic. It will also provide tools and training that will facilitate performing these activities. Currently, ELIXIR CZ involves eleven institutions - nine life science research centres and two IT infrastructures. ELIXIR CZ also creates a communication platform for life science research institutes in the Czech Republic. ELIXIR CZ is a node of the European ESFRI project ELIXIR and is strongly involved in its activities. The ELIXIR project was approved by the Competitiveness Council from ESFRI as one of three prioritised Research Infrastructures.
Publications
Total number of publications: 68
2019
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Computational Design of Stable and Soluble Biocatalysts
ACS Catalysis, year: 2019, volume: 9, edition: 2, DOI
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Computational Modelling of Metabolic Burden and Substrate Toxicity in Escherichia coli Carrying a Synthetic Metabolic Pathway
Microorganisms, year: 2019, volume: 7, edition: 11, DOI
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Computational Study of Protein-Ligand Unbinding for Enzyme Engineering
FRONTIERS IN CHEMISTRY, year: 2019, volume: 6, edition: JAN 2019, DOI
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Deciphering the Structural Basis of High Thermostability of Dehalogenase from Psychrophilic Bacterium Marinobacter sp. ELB17
Microorganisms, year: 2019, volume: 7, edition: 11, DOI
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Engineering enzyme access tunnels
BIOTECHNOLOGY ADVANCES, year: 2019, volume: 37, edition: 6, DOI
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Exploring the challenges of computational enzyme design by rebuilding the active site of a dehalogenase
Proceedings of the National Academy of Sciences of the United States of America, year: 2019, volume: 116, edition: 2, DOI
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Fast Screening of Inhibitor Binding/Unbinding using Novel Software Tool CaverDock
FRONTIERS IN CHEMISTRY, year: 2019, volume: 7, edition: OCT 29 2019, DOI
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NMDA Receptor Opening and Closing-Transitions of a Molecular Machine Revealed by Molecular Dynamics
Biomolecules, year: 2019, volume: 9, edition: 10, DOI
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Rapidly Display Glycan Symbols in 3D Structures: 3D-SNFG in LiteMol
Journal of Proteome Research, year: 2019, volume: 18, edition: 2, DOI
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Structural Biology and Protein Engineering of Thrombolytics
Computational and Structural Biology Journal, year: 2019, volume: 17, edition: 2019, DOI