Project information
Biomolecular Center
- Project Identification
- LN00A016
- Project Period
- 7/2000 - 12/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Centres
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jaroslav Koča, DrSc.
- Keywords
- Biomolecules, protein, oligonucleotides, NMR spectroscopy, computer simulations and modeling, protein engineering, DNA vaccines, bacteria "quorum systems"
- Cooperating Organization
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Institute of Biophysics
- Responsible person prof. RNDr. Jiří Šponer, DrSc.
- Responsible person doc. RNDr. Ivan Rychlík, Ph.D.
Biomolecular center is designed as an expert laboratory for studiyng the structure and properties of biologically relevant molecules and biopolymers, with main emphasis on proteins and nucleic acid fragments. On the horizontal level the Center will havea strong background in methods for studiing the biomolecules on the atomic level using NMR spectroscopy, molecular modeling and X-ray crystallography with appropriate support of biochemistry and molecular biology. The Center will be able to studythe biomolecular systems in the vertical direction starting with the atomic structure, through their in vitro properties to their function in living cells. From the very beginning, the Center will activelly participate in Ph.D programs (already now 14PhD. students). In the final stage, 25 core scientist will be employed in the Center with a significant support from postdoctoral fellows and PhD. students (2/3 of all coworkers). The group is involved in a large number of international projects.
Publications
Total number of publications: 127
2003
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Specificity and kinetics of oligosaccharide recognition by RSL, a fucose-binding lectin from the plant pathogen Ralstonia solanacearum.
XVII International Symposium on Glycoconjugates, year: 2003
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Structural and thermodynamical characterisation of interaction between a pseudomonas lectin and monosaccharides
12th European Carbohydrate Symposium, year: 2003
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Structural basis for oligosaccharide-mediated adhesion of P. aeruginosa in the lungs of cystic fibrosis patients
12th European Carbohydrate Symposium, year: 2003
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Structure and Dynamics of RNA K-turn Motifs
RNA klub, year: 2003
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Studium struktury a NMR parametrů N-substituovaných derivátů purinu
Chemické listy, year: 2003
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Studium tautomerních rovnováh purinových derivátů pomocí nízkoteplotní NMR spektroskopie a kvantově chemických výpočtů
Chemické listy, year: 2003, volume: 97, edition: 11
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Tautomerism of Purine Derivatives Investigated by Low-Temperature NMR and Theoretical Calculations
18th NMR Valtice - Meeting of Central European NMR Discussion Groups, year: 2003
2002
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15N NMR Spectroscopy in Structural Analysis
Current Organic Chemistry, year: 2002, volume: 6, edition: 1, DOI
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CDK2 activation and inhibition by phosphorylation, a molecular dynamics study
Materials in Structure Chemistry, Biology, Physics and Technology, year: 2002
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Cloning, expression and preliminary characterization of novel haloalkane dehalogenase DhmA from Mycobacterium avium N85
Applied and Environmental Microbiology, year: 2002, volume: 68, edition: 8