Project information
Molecular mechanisms of the cell proliferation and differentiation
- Project Identification
- GD204/08/H054
- Project Period
- 1/2008 - 12/2011
- Investor / Pogramme / Project type
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Czech Science Foundation
- Doctor grants
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jan Šmarda, CSc.
- prof. RNDr. Jiří Fajkus, CSc.
- doc. RNDr. Lenka Fajkusová, CSc.
- doc. RNDr. Jan Hejátko, Ph.D.
- doc. Mgr. Ctirad Hofr, Ph.D.
- Mgr. Jakub Horák, Dr. rer. nat.
- RNDr. Lubomír Janda, Ph.D.
- doc. RNDr. Jaromír Marek, Ph.D.
- doc. Mgr. Jan Paleček, Dr. rer. nat.
- prof. RNDr. Jana Šmardová, CSc.
- prof. RNDr. Renata Veselská, Ph.D., M.Sc.
- Mgr. Pavlína Zatloukalová, Ph.D.
- prof. RNDr. Zbyněk Zdráhal, Dr.
- Other MU Faculty/Unit
- Faculty of Informatics
- Keywords
- regulation of cell proliferation and differentiation, genomics and proteomics, plant, animal and microbial models, bioinformatics
Plants and animals evolved significantly different strategies of regulation of the cell proliferation and differentiation. Identification and comparison of molecular mechanisms driving those different strategies in plants, animals and microorganisms might contribute to the identification of their common principles. The project is based on collaboration of laboratories involved in the study of the processes of the cell proliferation and differentiation in those different model organisms including human beings. Collaboration of the laboratories with expertise in (i) molecular plant physiology, (ii) molecular mechanisms maintaining the genome stability, (iii) proliferation, differentiation and programmed cell death of cancer cells and (iv) bioinformatics will result into a multidisciplinary, while still functional team that will guarantee successful solution of scheduled tasks. Participation of multiple, recently collaborating laboratories including Core lab will allow effective employment of high-throughput instrumentation in the planned genomics and proteomics approaches.
Publications
Total number of publications: 87
2011
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Structure and binding specificity of the receiver domain of sensor histidine kinase CKI1 from Arabidopsis thaliana.
The Plant Journal, year: 2011, volume: 67, edition: 5, DOI
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The effects of wedelolactone on cancer cells depend on its redox state
Year: 2011, type: Conference abstract
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The Overexpression of Cathepsin D Senzitizes Brest Cancer Cells to TRAIL-induced Apoptosis
Year: 2011, type: Conference abstract
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The role of c-Myb in regulation of migration and invasivity of colon carcinoma cells
The Student Scientific Conference on Cancer Research, year: 2011
2010
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c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D
Year: 2010, type: Conference abstract
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Crystallization and initial X-ray diffraction studies of the flavoenzyme NAD(P)H:(acceptor) oxidoreductase (FerB) from the soil bacterium Paracoccus denitrificans
Acta crystallographica. Section F Structural biology and crystallization communications, year: 2010, volume: F66, edition: 4
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Dysfunction of Chromatin Assembly Factor 1 Induces Shortening of Telomeres and Loss of 45S rDNA in Arabidopsis thaliana
Plant Cell, year: 2010, volume: 22, edition: 8
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Enhancement of retinoid-induced cell differentiation in cancer therapy.
Year: 2010, type: Conference abstract
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Exprese CD133 a nestinu v buněčných liniích derivovaných z rhabdomyosarkomu
XXXIV. Brněnské onkologické dny - edukační sborník, year: 2010
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Expression profiling of neuroblastoma and medulloblastoma cell lines after combined treatment by all-trans retinoic acid and LOX/COX inhibitors.
Year: 2010, type: Conference abstract