Project information
Molecular mechanisms of the cell proliferation and differentiation
- Project Identification
- GD204/08/H054
- Project Period
- 1/2008 - 12/2011
- Investor / Pogramme / Project type
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Czech Science Foundation
- Doctor grants
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jan Šmarda, CSc.
- prof. RNDr. Jiří Fajkus, CSc.
- doc. RNDr. Lenka Fajkusová, CSc.
- doc. RNDr. Jan Hejátko, Ph.D.
- doc. Mgr. Ctirad Hofr, Ph.D.
- Mgr. Jakub Horák, Dr. rer. nat.
- RNDr. Lubomír Janda, Ph.D.
- doc. RNDr. Jaromír Marek, Ph.D.
- doc. Mgr. Jan Paleček, Dr. rer. nat.
- prof. RNDr. Jana Šmardová, CSc.
- prof. RNDr. Renata Veselská, Ph.D., M.Sc.
- Mgr. Pavlína Zatloukalová, Ph.D.
- prof. RNDr. Zbyněk Zdráhal, Dr.
- Other MU Faculty/Unit
- Faculty of Informatics
- Keywords
- regulation of cell proliferation and differentiation, genomics and proteomics, plant, animal and microbial models, bioinformatics
Plants and animals evolved significantly different strategies of regulation of the cell proliferation and differentiation. Identification and comparison of molecular mechanisms driving those different strategies in plants, animals and microorganisms might contribute to the identification of their common principles. The project is based on collaboration of laboratories involved in the study of the processes of the cell proliferation and differentiation in those different model organisms including human beings. Collaboration of the laboratories with expertise in (i) molecular plant physiology, (ii) molecular mechanisms maintaining the genome stability, (iii) proliferation, differentiation and programmed cell death of cancer cells and (iv) bioinformatics will result into a multidisciplinary, while still functional team that will guarantee successful solution of scheduled tasks. Participation of multiple, recently collaborating laboratories including Core lab will allow effective employment of high-throughput instrumentation in the planned genomics and proteomics approaches.
Publications
Total number of publications: 87
2009
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Mechanismus vazby SMH proteinů na telomerickou DNA
Chemické listy, year: 2009
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Možnosti modulace ATRA-indukované diferenciace neuroblastomových a meduloblastomových buněčných linií působením LOX/COX inhibitorů.
XXXIII. Brněnské onkologické dny - edukační sborník, year: 2009
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Novel fucose binding lectin domain from the human pathogen Bukholderia cenocepacia
Glycoconjugate Journal, year: 2009
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Protein c-Myb snižuje frekvenci apoptózy buněk karcinomu střeva bez účasti cyklooxygenázy 2
Chemické listy, year: 2009
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Studie možností ovlivnění antineoplastického efektu retinoidů jejich kombinovanou aplikací s LOX/COX inhibitory na modelu neuroblastomových buněčných linií.
XIX. Konferencia detských hematológov a onkologov Českej a Slovenskej republiky - zborník abstraktov, year: 2009
2008
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Analysis of interaction domains of plant telomere-binding proteins AtTRB1 and AtPOT1b
Year: 2008, type: Conference abstract
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Analýza exprese podjednotek NFkB u buněk leukemické linie BM2 metodou qRT-PCR
XII. Pracovní setkání biochemiků a molekulárních biologů. Sborník abstraktů., year: 2008
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Distinct effects of members of the TGFbeta proteins on differentiation of osteoclasts
ELSO Proceedings - Frontiers of cellular, developmental and molecular biology, year: 2008
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Expresní profil transkripčního faktoru NFkB v buňkách leukemické linie BM2
Študentská vedecká konferencia, 23.4.2008. Bratislava, Sborník príspevkov., year: 2008
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Expresní profily genů c-jun, c-fos a integrinu beta 3 v průběhu diferenciace buněk RAW264.7
Year: 2008, type: Conference abstract