Project information
Characterization of intrinsically disordered proteins
- Project Identification
- GF20-05789L
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Czech Science Foundation
- LA Grants
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Universität für Bodenkultur Wien
- Responsible person Chris Oostenbrink
We will characterize the conformational ensembles of RD-TyrH, Map2c and tau. We hypothesize that shifts in the conformational ensembles of these IDPs/IDRs are crucial to understand their function and will further develop integrative experimental and computational approaches to characterize these shifts.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 21
2024
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dGAE(297-391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy-Like Tau Filaments
Angewandte Chemie International Edition, year: 2024, DOI
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Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3zeta protein variants
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, year: 2024, volume: 266, edition: Pt 2, DOI
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How does phosphorylation affect interaction between 14-3-3ζ and Tau proteins?
Year: 2024, type: Conference abstract
2023
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14-3-3 dimer vs monomer – (dis)similarities in Tau protein binding
Year: 2023, type: Conference abstract
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Conformation and Affinity Modulations by Multiple Phosphorylation Occurring in the BIN1 SH3 Domain Binding Site of the Tau Protein Proline-Rich Region
Biochemistry, year: 2023, volume: 62, edition: 11, DOI
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Conformational changes upon phosphorylation of proline rich region of tau(210-240) peptide using molecular dynamic simulation
Year: 2023, type: Conference abstract
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Designing of Insecticides Against Bemisia tabaci targeting ecdysone receptor
Year: 2023, type: Conference abstract
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Interaction of selected drugs at dimer interface of human 14-3-3ζ protein
Year: 2023, type: Conference abstract
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Molecular dynamic simulation study of multiple phosphorylations at the proline rich region of tau(210-240) peptide
Year: 2023, type: Conference abstract
2022
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14-3-3 protein isoforms: mutual dimerization propensities screening kit
Year: 2022, type: Conference abstract