Project information
Characterization of intrinsically disordered proteins
- Project Identification
- GF20-05789L
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Czech Science Foundation
- LA Grants
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Universität für Bodenkultur Wien
- Responsible person Chris Oostenbrink
We will characterize the conformational ensembles of RD-TyrH, Map2c and tau. We hypothesize that shifts in the conformational ensembles of these IDPs/IDRs are crucial to understand their function and will further develop integrative experimental and computational approaches to characterize these shifts.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 21
2022
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A new fibrillization mechanism of β-lactoglobulin in glycine solutions
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, year: 2022, volume: 216, edition: SEP, DOI
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Biomolecular Complexation on the "Wrong Side": A Case Study of the Influence of Salts and Sugars on the Interactions between Bovine Serum Albumin and Sodium Polystyrene Sulfonate
Biomacromolecules, year: 2022, volume: 23, edition: 10, DOI
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Impact of Chromate and Dichromate on Lysozyme Stability: A Spectroscopic and Molecular Docking Investigation
Luminescence, year: 2022, volume: 37, edition: 6, DOI
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Impact of Phosphorylation for Tau210-240 Peptide and Interaction of Small Molecules and 14-3-3ζ Protein Studies Using Computational Methods
Year: 2022, type: Appeared in Conference without Proceedings
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Multiple approaches for protein phosphorylation: a story of 14-3-3
Year: 2022, type: Conference abstract
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Phosphomimicking mutations ≠ phosphorylation - a case study of 14-3-3 protein
Year: 2022, type: Conference abstract
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Phosphorylated and Phosphomimicking Variants May Differ—A Case Study of 14-3-3 Protein
Frontiers in Chemistry, year: 2022, volume: 10, edition: March, DOI
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Quantitation of Human 14-3-3ζ Dimerization and the Effect of Phosphorylation on Dimer-monomer Equilibria
Journal of Molecular Biology, year: 2022, volume: 434, edition: 7, DOI
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To homodimerize or to heterodimerize: story of 14-3-3 protein dimer formation
Year: 2022, type: Conference abstract
2021
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Cysteine Modification by Ebselen Reduces the Stability and Cellular Levels of 14-3-3 Proteins
Molecular Pharmacology, year: 2021, volume: 100, edition: 2, DOI