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Project information
Electrodes modified with nucleic acids and proteins. New tools in biochemical and biomedical research

Project Identification
GV204/97/K084
Project Period
1/1997 - 1/2001
Investor / Pogramme / Project type
Czech Science Foundation
  • Complex Projects
MU Faculty or unit
Faculty of Science
Cooperating Organization
Institute of Biophysics
  • Responsible person prof. RNDr. Emil Paleček, DrSc.
J. Heyrovský Institute of Physical Chemistry of the ASCR, v. v. i.
  • Responsible person doc. Ing. Ladislav Novotný, CSc.
Masaryk Memorial Cancer Institute Brno
  • Responsible person RNDr. Bořivoj Vojtěšek, DrSc.

This project of complex studies of biomacromolecule interactions with electrically charged surfaces is based on the recent progress reached in the proposers' laboratories (see the text) in the development of the electrochemical techniques and in the stud ies of interactions of nucleic acids and proteins with the mercury electrode and solid surfaces. In this project basic information about the adsorption/desorption, redox properties and structural features of DNA, RNA, oligonucleotides, proteins and small peptides at interfaces will be obtained. As a result of these studies electrochemical ultramicromethods will be developed including (a) fast response sensors of the DNA damage (b) fast response sensors of the DNA hybridization c new methods for studies of the interaction of DNA with specific proteins and anticancer drugs, etc. In addition information about the DNA local structures in neurological genetic diseases and about the DNA-p53 protein interactions in human cancer will be obtained. The main goal

Publications

Total number of publications: 83

2001

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